An emerging role for relaxin as a renal vasodilator.
نویسندگان
چکیده
Jennifer M Sasser,* Marshall D. Lindheimer, and Chris Baylis* *Department of Physiology and Functional Genomics, Department of Medicine, Division of Nephrology, University of Florida, Gainesville, Florida; Departments of Obstetrics & Gynecology and Medicine, and the Committee on Clinical Pharmacology, University of Chicago, Chicago, Illinois J Am Soc Nephrol 17: 2960–2961, 2006. doi: 10.1681/ASN.2006091009
منابع مشابه
Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans.
Relaxin is emerging as an important vasodilator of pregnancy and is being tested for afterload reduction in acute heart failure. However, the mechanisms underlying relaxin-induced vasodilation are incompletely understood. The aims of this study were to establish a new in vitro model for relaxin-induced vasodilation and to use this approach, as well as chronically instrumented, conscious rats, t...
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Sasser JM. The emerging role of relaxin as a novel therapeutic pathway in the treatment of chronic kidney disease. Am J Physiol Regul Integr Comp Physiol 305: R559–R565, 2013. First published July 24, 2013; doi:10.1152/ajpregu.00528.2012.— Emerging evidence supports a potential therapeutic role of relaxin in fibrotic diseases, including chronic kidney disease. Relaxin is a pleiotropic hormone, ...
متن کاملEmerging role of relaxin in renal and cardiovascular function.
Although traditionally associated with reproductive processes, relaxin is emerging as an important player in renal and cardiovascular function. Much of our recently acquired understanding of relaxin in this new context has arisen from studies of maternal renal and cardiovascular adaptations to pregnancy in rats where the hormone is turning out to be an important mediator. First, we highlight th...
متن کاملYoung Investigator Award Lecture of the Aps Water and Electrolyte Homeostasis
Sasser JM. The emerging role of relaxin as a novel therapeutic pathway in the treatment of chronic kidney disease. Am J Physiol Regul Integr Comp Physiol 305: R559–R565, 2013. First published July 24, 2013; doi:10.1152/ajpregu.00528.2012.— Emerging evidence supports a potential therapeutic role of relaxin in fibrotic diseases, including chronic kidney disease. Relaxin is a pleiotropic hormone, ...
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The uterine vasculature undergoes profound adaptations in response to pregnancy. Augmentation of endothelial vasodilator function and reduced smooth muscle reactivity are factors contributing to uterine artery adaptation and are critical for adequate placental perfusion. The peptide hormone relaxin has an important role in mediating the normal maternal renal vascular adaptations during pregnanc...
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عنوان ژورنال:
- Journal of the American Society of Nephrology : JASN
دوره 17 11 شماره
صفحات -
تاریخ انتشار 2006